Saturday, March 30, 2013

Personal Computer Just Got Way More Literal With - Geekosystem

Do you know what the Singularity is? It?s that apocryphal-unless-it-happens sci-fi-like event, championed by Ray Kurzweil, in which humans and machines merge and we as a species are forever transformed. None can say whether the the artificial mind and the real mind will become as one, but we?re making advances in that direction every day. Now bioengineers at Stanford University have made transistors from genetic materials in lieu of the semiconducting materials normally used. A nice big step toward Singularity.?Biological computers!

It starts with the transistor, the primary building block of the digital world and the reason we have cars, phones, and video games.

Published in Science, this new development?is the work of postdoctoral scholar of bioengineering?Jerome Bonnet and his team. They?re calling their bio-transistors ?transcriptors,? and they?re made from DNA and RNA. ?Transcriptors are the key component behind amplifying genetic logic,? says Bonnet.

This means engineers can compute inside living cells, giving them the ability to monitor what goes on around them or even toggle on and off cell reproduction. Transcriptors determine the flow of a specific protein or RNA polymerase (RNA-producing enzymes) in a strand of DNA, like electrons through a wire.

In electrical engineering, there is something called a logic-gate, another of the building blocks of a computer, which uses Boolean logic ? a system of 1s and 0s which represent on or off, open, or closed. Bonnet?s paper says their transcriptors have their own biological version, which they?re calling ?Boolean Integrase Logic? (?BIL gates? for short), and these are the third and final component of a complete biological computer.

So what?s the use of logic? Bonnet said the possibilities for logic are as endless in a biological setting as in electronics:

?You could test whether a given cell had been exposed to any number of external stimuli ? the presence of glucose and caffeine, for instance. BIL gates would allow you to make that determination and to store that information so you could easily identify those which had been exposed and which had not.?

The team used very specific enzyme combinations to control the flow of enzymes through DNA. ?The choice of enzymes is important,? he went on to say. ?We have been careful to select enzymes that function in bacteria, fungi, plants and animals, so that bio-computers can be engineered within a variety of organisms.?

As a fan of fungi, that?s intriguing to me! Computer toadstools are hopefully the future. Maybe.

But seriously, the application of this technology is wide open and Bonnet is happy to share his team?s work with the public:

?Most biotechnology has not yet been imagined. Let alone made true. By freely sharing important basic tools everyone can work better together.?

All right, so there won?t be any synthetic people walking around anytime soon, but it may not be too long before bio-computers can keep an eye on our insides and make sure we?re doing all right. How thoughtful!

(Stanford University via?Science Daily, images courtesy of imgfave.com, and ?DS on Flickr)

Relevant to your interests

Source: http://www.geekosystem.com/bio-computers-transcriptors/

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Alice Cooper, Doors guitarist playing at academy

SIOUX FALLS, S.D. (AP) ? A pair of Rock and Roll Hall of Fame members took the stage Thursday in South Dakota for the first show in a week of concerts benefiting a music academy for Sioux Falls Boys & Girls Clubs members.

Alice Cooper jammed with Robby Krieger of The Doors and a who's who of '80s glam and metal rockers to help christen the $3.6 million Brennan Rock & Roll Academy in Sioux Falls. Also taking the stage were Joey Allen of Warrant, former Skid Row frontman Sebastian Bach, bassist Chuck Garric and Eric Singer and Tommy Thayer of Kiss.

"These guys all know my songs, so I'll be doing four or five of my songs, and then a couple of Doors songs," Cooper told The Associated Press before the show.

Cooper, wearing black leather pants, a black vest, black jacket and black gloves, belted out The Doors' "Back Door Man," aptly channeling the late Jim Morrison as Krieger led on guitar.

Cooper then told tales of warming up for The Doors in the late 1960s before the band jumped into "Break on Through (To the Other Side)."

Earlier in the set, Krieger came out for a duet with Bach on the lesser known "Crystal Ship," the B-side to superhit "Light My Fire."

The all-star band also performed some Kiss songs, a cover of The Rolling Stones' "Brown Sugar" and a little Skid Row.

The $1,000-a-ticket concert is a fundraiser for the center, which is the brainchild of Sioux Falls native Chuck Brennan. Brennan, the founder of short-term lender Dollar Loan Center, based his idea on Cooper's Solid Rock Foundation in Phoenix.

Cooper said about 100 kids a night are flocking to his Solid Rock center, which opened about two years ago.

"If you take one kid out of a gang and get him involved in rock 'n' roll or get him involved in a guitar or bass or drums, you don't just change that kid, you change the neighborhood," he said.

The Sioux Falls academy has had the feel of an exclusive, intimate venue this week, but starting in April it will become the afternoon home for young people looking to learn or improve their skills in guitar, bass, drums, keyboards or vocals.

Lessons will be given in nine soundproof rehearsal rooms, five of which are wired to a professional mixing and recording studio. The four upstairs rehearsal rooms will honor Kiss, with each decorated as an homage to the band members' characters: The Demon, Starchild, Catman and Spaceman.

Kiss' Thayer, who grew up playing saxophone in a school music program before he ever touched a guitar, said the facility will spark kids' creative side.

"I'm blown away with this whole facility," Thayer said. "I think it's a great thing."

___

Follow Dirk Lammers on Twitter at http://www.twitter.com/ddlammers

Source: http://news.yahoo.com/alice-cooper-doors-guitarist-playing-academy-014421341.html

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Cell reprogramming during liver regeneration

Friday, March 29, 2013

During embryonic development, animals generate many different types of cells, each with a distinct function and identity.

"Although the identities of these cells remain stable under normal conditions, some cells can be persuaded to take on new identities, through reprogramming," says Ben Stanger, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology at the Perelman School of Medicine, University of Pennsylvania.

Researchers have been able to reprogram cells experimentally, but few have shown that cells can change their identities under normal physiological conditions in the body, particularly in mammals.

In the cover article of this month's issue of Genes and Development, Stanger, PhD candidate Kilangsungla Yanger, Yiwei Zong, PhD, and their colleagues, did just that in the liver of a mouse. Stanger is also an investigator in the Abramson Family Cancer Research Institute and the Department of Cell and Developmental Biology.

The adult liver contains two major cell types ? hepatocytes and biliary cells ? that differ dramatically in appearance and function. Hepatocytes are the main cell type in the liver, where they synthesize proteins and other macromolecules, and detoxify toxic substances. Biliary cells, on the other hand, line the bile ducts, which carry bile from the liver to the small intestine to help digest fats.

Using a sensitive method to tag and track how cells develop and differentiate, the researchers found that conditional expression of an activated Notch1 gene converted hepatocytes into biliary cells. Notch is an important receptor for relaying signals to tell cells how to develop.

What's more, after the researchers injured liver cells with a variety of toxins to stimulate wound healing, they found that over two to three weeks hepatocytes activated a biliary cell program on their own, acquiring the shape and function of biliary cells. These changes were dependent on the activation of endogenous Notch signaling.

"This is direct evidence that cells can be converted from one mature cell type to another in a live animal, as part of a normal response to injury," says Stanger. "We think that augmenting pre-existing cell reprogramming relationships may be another way to engineer cells for the treatment of diseases in which there are not enough bile ducts, such as cholestasis."

###

University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/

Thanks to University of Pennsylvania School of Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127525/Cell_reprogramming_during_liver_regeneration

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Which Movie Will Win the Box Office This Weekend?

From Channing Tatum and Dwayne Johnson kicking Cobra butt in G.I. Joe: Retaliation to Saoirse Ronan fighting against an alien species on Earth in The Host, here are the movies to check out this weekend. Plus, don't miss the films that have already hit theaters! Will you be grabbing your popcorn and catching one of them this weekend?

Source: http://www.ivillage.com/movie-reviews-what-see-weekend-gi-joe-and-host/1-a-530749?dst=iv%3AiVillage%3Amovie-reviews-what-see-weekend-gi-joe-and-host-530749

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Drone industry worries about privacy backlash

(AP) ? It's a good bet that in the not-so-distant future aerial drones will be part of Americans' everyday lives, performing countless useful functions.

A far cry from the killing machines whose missiles incinerate terrorists, these generally small, unmanned aircraft will help farmers more precisely apply water and pesticides to crops, saving money and reducing environmental impacts. They'll help police departments find missing people, reconstruct traffic accidents and act as lookouts for SWAT teams. They'll alert authorities to people stranded on rooftops by hurricanes and monitor evacuation flows.

Real estate agents will use them to film videos of properties and surrounding neighborhoods. States will use them to inspect bridges, roads and dams. Oil companies will use them to monitor pipelines, while power companies use them to monitor transmission lines.

With military budgets shrinking, drone makers have been counting on the civilian market to spur the industry's growth. But there's an ironic threat to that hope: Success on the battlefield may contain the seeds of trouble for the more benign uses of drones at home.

The civilian unmanned aircraft industry worries that it will be grounded before it can really take off because of fear among the public that the technology will be misused. Also problematic is a delay in the issuance of government safety regulations that are needed before drones can gain broad access to U.S. skies.

Some companies that make drones or supply support equipment and services say the uncertainty has caused them to put U.S. expansion plans on hold, and they are looking overseas for new markets.

"Our lack of success in educating the public about unmanned aircraft is coming back to bite us," said Robert Fitzgerald, CEO of The BOSH Group of Newport News, Va., which provides support services to drone users.

"The U.S. has been at the lead of this technology a long time," he said. "If our government holds back this technology, there's the freedom to move elsewhere ... and all of a sudden these things will be flying everywhere else and competing with us."

Since January, drone-related legislation has been introduced in more than 30 states, largely in response to privacy concerns. Many of the bills are focused on preventing police from using drones for broad public surveillance, as well as targeting individuals for surveillance without sufficient grounds to believe they were involved in crimes.

Law enforcement is expected to be one of the bigger initial markets for civilian drones. Last month, the FBI used drones to maintain continuous surveillance of a bunker in Alabama where a 5-year-old boy was being held hostage.

In Virginia, the state General Assembly passed a bill that would place a two-year moratorium on the use of drones by state and local law enforcement. The measure is supported by groups as varied as the American Civil Liberties Union on the left and the Virginia Tea Party Patriots Federation on the right.

Gov. Bob McDonnell is proposing amendments that would retain the broad ban on spy drones but allow specific exemptions when lives are in danger, such as for search-and rescue operations. The legislature reconvenes on April 3 to consider the amendments.

"Any legislation that restricts the use of this kind of capability to serve the public is putting the public at risk," said Steve Gitlin, vice president of AeroVironment, a leading maker of smaller drones, including some no bigger than a hummingbird

Seattle abandoned its drone program after community protests in February. The city's police department had purchased two drones through a federal grant without consulting the city council.

Drones "clearly have so much potential for saving lives, and it's a darn shame we're having to go through this right now," said Stephen Ingley, executive director of the Airborne Law Enforcement Association. "It's frustrating."

In some states economic concerns have trumped public unease. In Oklahoma, an anti-drone bill was shelved at the request of Republican Gov. Mary Fallin, who was concerned it might hinder growth of the state's drone industry. The North Dakota state Senate killed a drone bill in part because of concern that it might impede the state's chances of being selected by the Federal Aviation Administration as one of six national drone test sites, which could generate local jobs.

A bill that would have limited the ability of state and local governments to use drones died in the Washington legislature. The measure was opposed by The Boeing Co., which employs more than 80,000 workers in the state and which has a subsidiary, Insitu, that's a leading military drone manufacturer.

Although the Supreme Court has not dealt directly with drones, it has OK'd aerial surveillance without warrants in drug cases in which officers in a plane or helicopter spotted marijuana plants growing on a suspect's property. But in a case involving the use of ground-based equipment, the court said police generally need a warrant before using a thermal imaging device to detect hot spots in a home that might indicate that marijuana plants are being grown there.

In Congress, Rep. Ed Markey, D-Mass., co-chairman of the House's privacy caucus, has introduced a bill that prohibits the Federal Aviation Administration from issuing drone licenses unless the applicant provides a statement explaining who will operate the drone, where it will be flown, what kind of data will be collected, how the data will be used, whether the information will be sold to third parties and the period for which the information will be retained.

Sentiment for curbing domestic drone use has brought the left and right together perhaps more than any other recent issue. "The thought of government drones buzzing overhead and constantly monitoring the activities of law-abiding citizens runs contrary to the notion of what it means to live in a free society," Sen. Charles Grassley, R-Iowa, said at a recent hearing of the Senate Judiciary Committee.

Privacy advocates acknowledge the many good uses of drones. In Mesa County, Colo., for example, an annual landfill survey using manned aircraft cost about $10,000. The county recently performed the same survey using a drone for about $200.

But drones' virtues can also make them dangerous, they say. Their low cost and ease of use may encourage police and others to conduct the kind of continuous or intrusive surveillance that might otherwise be impractical. Drones can be equipped with high-powered cameras and listening devices, and infrared cameras that can see people in the dark.

"High-rise buildings, security fences or even the walls of a building are not barriers to increasingly common drone technology," Amie Stepanovich, director of the Electronic Privacy Information Council's surveillance project, told the Senate panel.

Civilian drone use is limited to government agencies and public universities that have received a few hundred permits from the FAA. A law passed by Congress last year requires the FAA to open U.S. skies to widespread drone flights by 2015, but the agency is behind schedule and it's doubtful it will meet that deadline. Lawmakers and industry officials have complained for years about the FAA's slow progress.

The FAA estimates that within five years of gaining broader access about 7,500 civilian drones will be in use.

Sen. Rand Paul, R-Ky., recently drew attention to the domestic use of drones when he staged a Senate filibuster, demanding to know whether the president has authority to use weaponized drones to kill Americans on American soil. The White House said no, if the person isn't engaged in combat. But industry officials worry that the episode could temporarily set back civilian drone use.

"The opposition has become very loud," said Gitlin of AeroVironment, "but we are confident that over time the benefits of these solutions (drones) are going to far outweigh the concerns, and they'll become part of normal life in the future."

___

Associated Press writer Michael Felberbaum in Richmond, Va., contributed to this report.

___

Follow Joan Lowy on Twitter: http://www.twitter.com/AP_Joan_Lowy

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-29-Everyday%20Drones/id-aaae4985408342848295f731e6ad3aa9

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Friday, March 29, 2013

Marital conflict causes stress in children, may affect cognitive development

Mar. 28, 2013 ? Marital conflict is a significant source of environmental stress for children, and witnessing such conflict may harm children's stress response systems which, in turn, may affect their mental and intellectual development.

These conclusions come from a new study by researchers at Auburn University and the Catholic University of America. The study appears in the journal Child Development.

Researchers looked at 251 children from a variety of backgrounds who lived in two-parent homes. The children reported on their exposure to marital conflict when they were 8, providing information on the frequency, intensity, and lack of resolution of conflicts between their parents. The study gauged how children's stress response system functioned by measuring respiratory sinus arrhythmia (RSA), an index of activity in the parasympathetic branch of the body's stress response system. RSA has been linked to the ability to regulate attention and emotion. Children's ability to rapidly solve problems and quickly see patterns in new information also was measured at ages 8, 9, and 10.

Children who witnessed more marital conflict at age 8 showed less adaptive RSA reactivity at 9, but this was true only for children who had lower resting RSA. In addition, children with lower baseline RSA whose stress response systems were also less adaptive developed mental and intellectual ability more slowly.

"The findings provide further evidence that stress affects the development of the body's stress response systems that help regulate attention, and that how these systems work is tied to the development of cognitive ability," explains J. Benjamin Hinnant, assistant professor of psychology at the Catholic University of America and one of the researchers.

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The above story is reprinted from materials provided by Society for Research in Child Development, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. J. Benjamin Hinnant, Mona El-Sheikh, Margaret Keiley, Joseph A. Buckhalt. Marital Conflict, Allostatic Load, and the Development of Children's Fluid Cognitive Performance. Child Development, 2013; DOI: 10.1111/cdev.12103

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/a7w-l5GLmP4/130328080225.htm

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Dax Shepard & Kristen Bell Welcome Baby Girl!

Dax Shepard & Kristen Bell Welcome Baby Girl!

Dax Shepard & Kristen Bell picsAdorable couple Kristen Bell and Dax Shepard have welcomed their first child. The “Parenthood” actor, 38, announced his “Forgetting Sarah Marshall” fiance, 32, had given birth to a baby girl on his Twitter page. Dax revealed the very presidential name they gave their daughter, Lincoln Bell Shepard. Shepard joked around, writing, “She has her mom’s ...

Dax Shepard & Kristen Bell Welcome Baby Girl! Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/03/dax-shepard-kristen-bell-welcome-baby-girl/

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